What Vitamins Help Prevent Dementia? Here’s What Science Says

Written by Nguyenjessica 

Published on July 10 2025

Dementia is a growing concern, especially as we live longer. While there’s no magic bullet to prevent it, research suggests that certain vitamins can play a major role in maintaining brain health and possibly delaying or lowering your risk of dementia. So, which ones actually matter?

Key Points

B vitamins (especially B6, B9, and B12) support memory and reduce homocysteine levels.

Vitamin D is linked to lower dementia risk, especially in older adults.

Vitamin E offers antioxidant protection to brain cells.

Omega-3 fatty acids (not a vitamin but often grouped with supplements) may slow cognitive decline.

A balanced diet is more effective than megadosing on supplements.

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Table of content

B Vitamins: The Brain's Best Friends

Vitamin D: The Sunshine Nutrient

Vitamin E: Brain Protection from Oxidative Stress

Omega-3s: Bonus Brain Support

Should You Take Supplements?

B Vitamins: The Brain’s Best Friends

B6, B9 (folate), and B12

These vitamins are crucial for brain function and mental clarity. They help regulate homocysteine—a chemical in your blood that, when too high, is linked to brain shrinkage and memory problems.

What the research says:
A 2010 Oxford study found that seniors with mild memory issues had slower brain shrinkage when given B vitamins daily for 2 years. That’s a big deal.

Where to find them:

B6: Poultry, fish, bananas, potatoes

B9: Leafy greens, beans, fortified cereals

B12: Eggs, meat, dairy, fortified plant milk

Who might need extra:
Vegans, vegetarians, and older adults often have low B12 levels.

Vitamin D: The Sunshine Nutrient

Vitamin D is more than just a bone booster—it may be vital for your brain. Low levels are linked to higher risks of dementia and Alzheimer’s.

Recent findings:
A 2023 study published in Neurology showed that people with higher vitamin D levels had better cognitive function and fewer signs of dementia on brain scans.

Sources:

Sunlight (15–20 min/day)

Fatty fish like salmon and mackerel

Fortified foods

Supplements (especially for people in northern areas or with darker skin)

 

Vitamin E: Brain Protection from Oxidative Stress

Vitamin E acts as an antioxidant, protecting your brain cells from damage caused by free radicals.

Research insight:
A study in JAMA (2002) linked higher intake of Vitamin E from food—not supplements—to a lower risk of Alzheimer’s.

Get it from:

Nuts (almonds, hazelnuts)

Seeds (sunflower)

Spinach, avocados, and vegetable oils

But don’t overdo it—high-dose vitamin E supplements have been associated with health risks. Stick to food-based sources unless advised by a doctor.

Omega-3s: Bonus Brain Support

Okay, not a vitamin, but still worth mentioning. Omega-3 fatty acids (especially DHA) found in fish oil may help slow mental decline.

Clinical data:
A 2015 meta-analysis suggested that omega-3 supplementation showed small but real benefits for people with mild cognitive impairment.

Best sources:

Salmon, tuna, sardines

Flaxseeds, chia seeds, walnuts

Fish oil or algae supplements
 

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Should You Take Supplements?

Maybe—but food first.
Supplements can help if you have a deficiency, but research consistently shows that getting nutrients from whole foods is better for your body and brain.

Talk to your doctor if you:

Are over 60

Follow a restricted diet (vegan, keto)

Have digestive issues or low energy

Spend little time in the sun

Blood tests can identify deficiencies, and a doctor can guide you on safe dosing.

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