Melatonin and Alzheimer’s: Could the Sleep Hormone Slow Cognitive Decline?

Written by Nguyenjessica

Published on July 16 2025

Melatonin, the hormone known for regulating our sleep-wake cycle, has recently gained attention for its potential role in Alzheimer’s disease. Can this common over-the-counter supplement really help slow memory loss or even protect the brain? Let’s explore the science, potential benefits, and what experts are saying.

Melatonin and Alzheimer’s: Could the Sleep Hormone Slow Cognitive Decline?

Key Points

Melatonin helps regulate sleep, which is critical for brain health.

Poor sleep is strongly linked to the progression of Alzheimer’s.

Some studies suggest melatonin may reduce brain inflammation and plaque buildup.

Evidence is still limited—consult your doctor before using melatonin for cognitive support.

Lifestyle factors like light exposure and sleep hygiene are just as important.

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Table of content

What Is Melatonin?

Sleep and Alzheimer’s: The Missing Link

How Might Melatonin Help?

Should You Take Melatonin?

Natural Ways to Support Melatonin Levels

What Is Melatonin?

Melatonin is a natural hormone produced by your brain’s pineal gland, primarily at night. It helps signal to your body that it’s time to sleep. You can also buy it as a supplement to treat insomnia or jet lag.

Sleep and Alzheimer’s: The Missing Link

Sleep is vital for memory consolidation and clearing toxins from the brain. Poor sleep is common in early Alzheimer’s, and studies show that chronic sleep deprivation may speed up cognitive decline. So, improving sleep isn’t just about feeling rested—it might protect your brain.

How Might Melatonin Help?

Researchers believe melatonin could play several roles in fighting Alzheimer’s:

Reducing amyloid-beta plaque buildup – a hallmark of Alzheimer’s.
Lowering oxidative stress – melatonin is a powerful antioxidant.
Calming brain inflammation – which can damage neurons.
Regulating circadian rhythms – often disrupted in dementia patients.

Should You Take Melatonin?

If you or a loved one with Alzheimer’s struggles with sleep, melatonin may be worth discussing with your doctor. Start with a low dose (0.5–3mg) and monitor for side effects like daytime drowsiness or vivid dreams.

Remember: melatonin is a supplement, not a medication. It should be part of a broader care plan, not a standalone treatment.